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Because of the pivotal role of CD4+ T cells in the immunopathogenesis of human rheumatoid arthritis (RA), inhibition of T cell function has been a major therapeutic goal. However, only limited success has been achieved in RA and other rheumatic diseases. It is well recognized that several immunosuppressive agents, including methotrexate and corticosteroids, can inhibit T cell function. Recent evidence has demonstrated that other immunosuppressive agents, including leflunomide, cyclosporine A, azathioprine, cyclophosphamide, and tacrolimus, can also effectively suppress T cell function in vitro. 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